OSOPIA® – Synthetic Graft Material with 3DI Surface Technology

OSOPIA® – Synthetic Graft Material with 3DI Surface Technology

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OSOPIA® is a synthetic Biphasic Calcium Phosphate (BCP) manufactured using an innovative proprietary process that creates a unique active surface on the graft. It is mineralized like FDBA and has a unique 3DI surface that closely mimics the properties of DFDBA. Therefore it resembles a mix of FDBA and DFDBA without the problematic safety and ethical issues of using allograft bone.


Slow resorption profile providing continuous remodeling process for 100% vital bone. Resorption times closely mimics traditional allograft time frames and can be used in similar indications.


3DI (three-dimensional integrated) microarchitecture is an excellent surface for osteoblast activity. Osopia’s unique micropore size between 0.3 and 1.1 microns results in better bone formation in extraction sockets or sinuses.


Synthetic graft concept designed for maximum product safety and performance. Socially conscious raw materials and no risk of disease transmission.


OSOPIA can be used in following indications:

  • Sinus lift
  • Filling of alveolar defects after tooth extraction (for ridge preservation or delayed implant placement >6 months)


Miron RJ,Sculean A, Shuang Y,Bosshardt DD, Gruber R, Buser D, Chandad F,Zhang Y. Osteoinductive potential of a novel biphasic calcium phosphate bone graft in comparison with autographs, xenografts, and DFDBA. Clin Oral Implants Res. 2016 Jun;27(6):668-75. doi: 10.1111/clr.12647. (IF = 3.624)

Miron RJ, Shuang Y, Bosshardt DD, Caballé-Serrano J, Chandad F, Zhang Y. Osteogenic gene array of osteoblasts cultured on a novel osteoinductive biphasic calcium phosphate bone grafting material. Clin Oral Investig. 2017 Apr;21(3):801-808. doi: 10.1007/s00784-016-1825-0. Epub 2016 Apr 23. (IF = 2.308)

Miron RJ, Zhang Q, Sculean A, Buser D, Pippenger BE, Dard M, Shirakata Y, Chandad F, Zhang Y. Osteoinductive potential of 4 commonly employed bone grafts. Clin Oral Investig. 2016 Nov;20(8):2259-2265. (IF = 2.308)

Zhang Y, Shuang Y, Zhou W, Fu H, Qian L, Miron RJ. Addition of a synthetically fabricated osteoinductive biphasic calcium phosphate bone graft to BMP2 improves new bone formation. Clin Implant Dent Relat Res. 2016 Dec;18(6):1238-1247. doi: 10.1111/cid.12384. Epub 2015 Oct 28. (IF = 2.939)

Miron RJ, Zhang Y. The Arrival of Synthetic Bone Grafts with Osteoinductive Potential. J J Dent Res. 2014, 1(1): 002.


Barroso-Panella A, Gargallo-Albiol J, Hérnandez-Alfaro FEvaluation of Bone Stability and Esthetic Results After Immediate Implant Placement Using a Novel Synthetic Bone Substitute in the Anterior Zone: Results After 12 Months. Int J Periodontics Restorative Dent. 2018 Mar/Apr;38(2):235-243. doi: 10.11607/prd.2863.