THE GRAFT® – High Porocity Porcine Cancellous Xenograft

THE GRAFT® – High Porocity Porcine Cancellous Xenograft

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Description

THE GRAFT®

Natural, mineralized bone graft substitute derived from deproteinized porcine cancellous bone.

Natural Cancellous Bone
THE Graft is a natural, mineralized bone graft substitute derived from deproteinized porcine cancellous bone and is structurally similar to human tissue.1,2 THE Graft has a high level of porosity combined with the naturally occurring interconnectivity of cancellous bone.3

Optimal Volume Retention
The natural structure of porcine cancellous bone ensures the stabilization of the defect and improves bone regeneration.4

Increased Efficiency
High porosity and early remodeling improves clinical performance.3

Safe & Biocompatible
The combination of porcine origin and an efficient treatment process offers an optimized safety and biocompatibility profile.3 Due to the proprietary manufacturing process, potential immunogenic organic elements are removed while the native material structure is maintained.

Availability

  • .25 g / 0.6 cc Vials, 250-1000 micron granule size
  • .50 g / 1.2 cc Vials, 250-1000 micron granule size
  • 1.o g / 2.4 cc Vials, 250-1000 micron granule size
  • 2.0g / 4.8 cc Vials, 250-1000 micron granule size

Overview

OPTIMAL VOLUME RETENTION

Native natural structure ensures defect stabilization and improved bone regeneration

THE Graft has a high specific surface area allowing more bone apposition. The clinical potential of THE Graft has been confirmed in an in vivo pre-clinical study. Rabbit calvarial defects were filled with either THE Graft or natural DBBM and covered with resorbable collagen membranes.

Ingrowth of blood vessels and connective tissue as well as the regeneration of immature woven bone were observed in week 2. In week 8, a large number of osteoblasts and new bone were observed around the augmentation material in particular for THE Graft. At the same time, the amount of residual particles was lower for THE Graft than for DBBM, indicating that THE Graft was partially resorbed and remodeled.

INCREASED EFFICIENCY

High porosity and early remodeling improve clinical performance

With 72.4 %, THE Graft has a higher level of porosity than comparable preparations of bovine origin (63.5 %–71.2 %), and almost reaches the level of human bone (76.5 %).3,5 The high porosity of THE Graft results in a quicker absorption of liquids (e.g., blood) in comparison to natural DBBM. This not only facilitates the application of the material but is also clinically relevant.

In a comparative study, rabbit calvarial defects were filled with either THE Graft or natural DBBM and covered with a non-resorbable PTFE membrane.

THE Graft showed a consistently higher rate of new bone formation than natural DBBM, particularly in the later study period after 8 weeks. The newly formed bone in the THE Graft test group also showed a much better bone quality than in the control group with DBBM (illustrated by a higher ratio of mature lamellar bone to loose woven bone for THE Graft versus DBBM (14.8 ± 11.3 versus 3.3 ± 2.0)), which indicates the early remodeling.

SAFE & BIOCOMPATIBLE

Optimal safety and biocompatibility profile

The combination of porcine origin with the high level of purity enables predictable bone growth without risking an immunogenic reaction. Thanks to the highly efficient, patented manufacturing process, THE Graft is also completely free from any organic components that could be a potential cause of infection or immune reaction.

The high biocompatibility of THE Graft has been confirmed by an in vitro cell study. THE Graft therefore encourages cell adhesion to the same extent as the established natural DBBM and offers optimal conditions for vital cell growth.

Indications

THE Graft as a therapeutic option for successful bone augmentation

THE Graft can be used for the following indications:

  • Augmentation of peri-implant defects (e.g., dehiscence and fenestration defects around implants)
  • Filling of extraction sockets
  • Sinus lift
  • Alveolar ridge augmentation or reconstruction (Guided bone regeneration “GBR” – e.g., lateral/horizontal augmentation)
  • Filling of bone defects (e.g., after apicoectomy or cystectomy)
  • Filling of periodontal bone defects (e.g., intrabony or furcation defects)